Do you know if you are suffering from Chronic Candida? It can be
very easy to tell. That is why we have developed this important questionnaire.
This questionnaire is designed for adults and the scoring system isn't
appropriate for children. It lists factors in your medical history which promote
the growth of Candida Albicans (Section A), and symptoms commonly found in individuals
with yeast-connected illness (Sections B and C).
Leaky Gut Syndrome
The lining of the intestines is a barrier that normally only allows properly digested fats, proteins,
and starches pass through and enter the bloodstream. It allows substances to pass in several ways.
Chloride, potassium, magnesium, sodium and free fatty acids diffuse through intestinal cells. Amino acids,
fatty acids, glucose, minerals, and vitamins also cross through cells, but they do it by another mechanism
called active transport.
There's a third way substances can pass through. The spaces in between the cells that line the intestines
are normally sealed. These tight junctions are called desmosomes. When the intestinal lining becomes
irritated, the junctions loosen and allow unwanted larger molecules in the intestines to pass through
into the blood. These unwanted substances are seen by the immune system as foreign (because they aren't
normally present in blood). This triggers an antibody reaction.
When the intestinal lining becomes further damaged, even larger substances, such as disease-causing
bacteria, undigested food particles, and toxins, pass directly through the damaged cells. Again, the
immune system is alarmed and antibodies and substances called cytokines are realeased. Cytokines alert
white blood cells to fight the particles. This fight produces oxidants, which cause irritation and
inflammation throughout the body.
Symptoms of Leaky gut syndrome / Intestinal permeability
Symptoms include: abdominal pain, asthma, chronic joint pain, chronic muscle pain, confusion, fuzzy or foggy
thinking, gas, indigestion, mood swings, nervousness, poor immunity, recurrent vaginal infections, skin rashes,
diarrhea, bed-wetting, recurrent bladder infections, poor memory, shortness of breath, constipation, bloating,
aggressive behavior, anxiety, fatigue, feeling toxic.
Leaky gut syndrome is associated with the following conditions:
Causes of Leaky Gut Syndrome / Intestinal Permeability
- Autoimmune disease
- Celiac disease
- Crohn's disease
- Environmental illness
- Inflammatory joint disease / arthritis
- Intestinal infections
- Pancreatic insufficiency
- Ulcerative colitis
- Chronic fatigue syndrome
- Food allergies and sensitivities
- Liver dysfunction
- Rheumatoid arthritis
- Irritable bowel syndrome
What is Leaky Gut Syndrome?
- Chronic stress
- Intestinal infections
- Small intestine bacterial overgrowth
- Environmental contaminants
- Excess alcohol
- Poor diet
- NSAIDS and other medications
The purpose of the gastro-intestinal (GI) tract, or gut, is multi-fold. Basically, it:
i) Digests foods
ii) Absorbs small food particles to be converted into energy.
iii) Carries nutrients like vitamins and minerals attached to carrier proteins across
the gut lining into the bloodstream.
iv) Contains a major part of the chemical detoxification system of the body.
v) Contains immunoglobulins or antibodies that act as the first line of defence
Leaky gut syndrome (LGS) is a poorly recognised but extremely common problem. It is rarely tested for.
Essentially, it represents a hyper-permeable intestinal lining. In other words, spaces develop between
the cells of the gut wall, and bacteria, toxins and food leak through. The official definition is an
increase in permeability of the intestinal mucosa to luminal macromolecules, antigens and toxins associated
with inflammatory degenerative and/or atrophic mucosal damage.
The Mucosal Barrier
The barrier posed by the intestinal mucosa is, even in normal subjects, an incomplete one.
Small quantities of molecules of different sizes and characteristics cross the intact epithelium
by both active and passive mechanisms. The route by which such transfer occurs is, at least in part,
dependent on molecular size. Molecules up to about 5000 Daltons in size cross the epithelial membrane
of the microvilli. Larger molecules may utilise an intercellular pathway or depend on being taken up
by endocytosis entering the cell at the base of the microvilli.
How Does The Gut Become Leaky?
Once the gut lining becomes inflamed or damaged, this disrupts the functioning of the system. The spaces
open up and allow large food antigens, for example, to be absorbed into the body. Normally the body
sees only tiny food antigens. When it sees these new, larger ones, they are foreign to the body's defence
system. So the attack results in the production of antibodies against once harmless, innocuous foods.
Isn't Leakier Better?
It might sound good that the gut can become leaky, because it would seem that the body would be better
able to absorb more amino acids, essential fatty acids, minerals and vitamins. For the body to absorb a
mineral it does not just slowly diffuse across the gut membrane it must be attached to a carrier protein.
This protein hooks onto the mineral and actually carries it across the gut wall into the bloodstream.
However, when the intestinal lining is damaged through inflammation these carrier proteins get damaged
as well, so now the victim is vulnerable to developing mineral and vitamin deficiencies.
The 7 stages of the 'inflamed' gut.
1 . When the gut is inflamed, it does not absorb nutrients and foods properly and so fatigue and bloating can occur.
2. As mentioned previously, when large food particles are absorbed there is the creation of food allergies and new symptoms.
3. When the gut is inflamed the carrier proteins are damaged so nutrient deficiencies can occur.
4. Likewise when the detoxification pathways that line the gut are compromised, chemical sensitivity can arise.
Furthermore the leakage of toxins overburdens the liver so that the body is less able to handle everyday chemicals.
5. When the gut lining is inflamed the protective coating of lgA (immunoglobulin A) is adversely affected and the body
is not able to ward off protozoa, bacteria, viruses and yeasts.
6. When the intestinal lining is inflamed, bacteria and yeasts are able to trans-locate. This means that they are
able to pass from the gut lumen or cavity, into the bloodstream and set up infection anywhere else in the body.
7. The worst symptom is the formation of antibodies. Sometimes these leak across and look similar to antigens on
our own tissues. Consequently, when an antibody is made to attack it, it also attacks our tissue. This is probably
how autoimmune disease start.